$PROBLEM
$DATA NMDATAHW7.CSV
$INPUT ID TIME DV
$PRED

CL=THETA(1)*EXP(ETA(1))     ;CLEARANCE WITH BETWEEN SUBJECT VAR
VD=THETA(2)*EXP(ETA(2))     ;VOLUME WITH BETWEEN SUBJECT VAR
W=THETA(3)                  ;ADDITIVE ERROR AS A SD 
K=CL/VD                     ;COMPUTE HYBRID K
PRE=4000*EXP(-K*TIME)/VD    ;PREDICTION
Y=PRE+W*EPS(1)
RES1=(PRE-DV)/W
$THETA
   (0,5)
   (0,20)
   (0,1)
$OMEGA BLOCK(1) .01
$OMEGA BLOCK(1) .01
$SIGMA 1 FIX
$EST PRINT=1 MAXEVALS=9999 METH=1
$COV PRINT=E
$TABLE RES1 NOPRINT NOAPPEND ONEHEADER FILE=THW7.TXT
;